Table 2.

Enriched canonical pathways between SmallAir epithelia obtained from healthy donors and from patients with COPD. The Z score determines whether the changes in gene expression for the known genes of each biological pathway are consistent with what is expected from the literature (Z score positive) or if the changes are inversely correlated with the literature (Z score negative)

Canonical Pathways	z-score
Role of Hypercytokinemia/hyperchemokinemia in the Pathogenesis of Influenza	3.16
Systemic Lupus Erythematosus In B Cell Signaling Pathway	2.83
Interferon Signaling	2.53
IL-17 Signaling	2.45
Role of MAPK Signaling in Inhibiting the Pathogenesis of Influenza	2.24
Regulation Of The Epithelial Mesenchymal Transition By Growth Factors Pathway	2.00
Estrogen Receptor Signaling	2.00
HIF1α Signaling	2.00
Activation of IRF by Cytosolic Pattern Recognition Receptors	1.34
Tumor Microenvironment Pathway	1.34
Hepatic Fibrosis Signaling Pathway	1.34
Acute Phase Response Signaling	1.00
MSP-RON Signaling In Macrophages Pathway	1.00
Leukocyte Extravasation Signaling	1.00
Adrenomedullin signaling pathway	1.00
Colorectal Cancer Metastasis Signaling	1.00
Dendritic Cell Maturation	1.00
Neuroinflammation Signaling Pathway	0.82
Coronavirus Pathogenesis Pathway	0.33
Sirtuin Signaling Pathway	-1.34