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. 2024 Apr 3;20:134. doi: 10.1186/s12917-024-03984-2

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© The Author(s) 2024, corrected publication 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Quercetin regulation of P53 as well as cell cycle induced by SADS-CoV infection (A) Cell lysates were collected at different time points and total RNA was extracted, and the P53 gene mRNA profile was detected using RT-qPCR. (B) Effects of SADS-CoV and quercetin on P53 protein levels and phosphorylation levels. (C) Cells were collected to analyze cell cycle distribution by flow cytometry. Results are from one of three independent experiments (n = 3), and asterisks in the graphs indicate significant differences (*P < 0.05; **P < 0.01; ***P < 0.001; ns: not significant)