Table 2.

Study assessments and registrations

Assessment/registration	Baseline	3-month follow-up	12-month follow-up	Long-term follow-up
Demographics	x
Medical history	x
Medication use	x
Admission NIHSS score	x
Symptom onset and admission time	x
Acute treatment	x
Standard blood chemistry at admission	x
Pre-stroke mRS	x
IQCODE	x
Height, weight and BP	x	x	x
Smoking and alcohol use	x
MoCA	x	x	x
PASE	x	x	x
WHO-5	x	x	x
MDI	x	x	x
Educational level	x
New vascular events		x	x	x
Functional outcome: mRS		x	x
Stroke classification: TOAST and OSCP		x
RBANS		x	x
Blood sample for EVs*	x	x
Blood sample for APOE genotyping		x
MRI**	x		x
Dementia				x

*Blood sample for EVs is drawn 24 h (+/- 8 h) after admission

**Baseline MRI is performed 24 h (+/- 6 h) after acute MRI on admission

NIHSS: National Institutes of Health Stroke Scale, mRS: modified Rankin scale, IQCODE: Informant Questionnaire on Cognitive Decline in the Elderly, BP: blood pressure, MoCA: Montreal Cognitive Assessment, PASE: Physical Activity Scale for the Elderly, WHO-5: World Health Organisation Five Well-Being Index, MDI: Major Depression Inventory, TOAST: trial of Org 10,172 in Acute Stroke Treatment, OSCP: Oxfordshire Community Stroke Project Classification, RBANS: Repeatable Battery for the Assessment of Neuropsychological Status, EVs: extracellular vesicles, APOE: apolipoprotein E, MRI: magnetic resonance imaging