Table 2.
Baseline characteristics based on kidney function and trajectories (as described in Fig. 1)
| Variable | Category | All | Kidney Function at day 5 | |||||
|---|---|---|---|---|---|---|---|---|
| Normal throughout | Developed new AKI | AKI II/III throughout | Renal recovery from AKI II/III | p-value | Missing % | |||
| n | 137 | 52 | 11 | 51 | 23 | |||
| Age | 54 [47, 68] | 50 [41, 69] | 52 [51, 67] | 57 [48, 66] | 54 [48, 68] | 0.776 | 0.7 | |
| Gender | Male | 91 (66) | 34 (65) | 6 (55) | 38 (75) | 13 (57) | 0.340 | – |
| Female | 46 (34) | 18 (35) | 5 (45) | 13 (25) | 10 (43) | |||
| Ethnicity | Asian | 4 (3) | 3 (6) | 0 | 1 (2) | 0 | 0.868 | 3.6 |
| Black | 9 (7) | 2 (4) | 0 | 5 (10) | 2 (9) | |||
| Caucasian | 118 (86) | 43 (83) | 11 (100) | 43 (84) | 21 (91) | |||
| Other | 1 (1) | 1 (2) | 0 | 0 | 0 | |||
| Missing | 5 (4) | 3 (6) | 0 | 2 (4) | 0 | |||
| Season | Summer | 68 (50) | 27 (52) | 6 (55) | 20 (39) | 15 (65) | 0.201 | 0.0 |
| Winter | 69 (50) | 25 (48) | 5 (45) | 31 (61) | 8 (35) | |||
| CRP (Day 0) [mg/dL] | 123 [54, 253] | 97 [53, 144] | 117 [84, 300] | 161 [68, 305] | 110 [43, 218] | 0.037 | 11.7 | |
| Serum 25(OH)D on day 0 [nmol/L] | 18 [10, 31] | 20 [12, 34] | 32 [14, 40] | 14 [9, 26] | 19 [9, 35] | 0.076 | 6.6 | |
| Serum 1,25(OH)2D on day 0 [pmol/L] | 50 [28, 68] | 54 [33, 69] | 63 [36, 106] | 41 [26, 58] | 36 [26, 56] | 0.069 | 5.1 | |
| Calcium (Day 0) [mmol/L] | 1.1 [1.1,1.2] | 1.1 [1.1,1.2] | 1.1 [1.1,1.2] | 1.1 [1.1,1.2] | 1.1 [1.1,1.2] | 0.833 | 6.6 | |
| APACHE II score (on admission) | 18 [14, 21] | 14 [12, 17] | 15 [12, 16] | 21 [19, 23] | 20 [17, 24] | < 0.001 | 0.0 | |
| SOFA minus renal score (Day 0) | 10 [7, 12] | 8 [7, 10] | 9 [6, 9] | 11 [9, 13] | 10 [8, 12] | < 0.001 | 6.6 | |
| ICU mortality | 25 (18) | 4 (7.7) | 1 (9) | 18 (35.3) | 2 (8.7) | 0.002 | - | |
| Hospital mortality | 31 (23) | 5 (9.6) | 1 (9) | 22 (43.1) | 3 (13) | < 0.001 | 1.5 | |
| 30-day mortality | 31 (23) | 5 (9.6) | 1 (9) | 23 (45.1) | 2 (8.7) | 0.001 | 5 | |
| Length of stay in ICU | 14 [8, 23]] | 10 [5, 15] | 16 [10, 19] | 18 [10, 30] | 18 [8, 27] | 0.010 | 29 | |
AKI Acute kidney injury, APACHE Acute physiology and chronic health evaluation, CRP C-reactive protein, ICU Intensive Care Unit, SOFA Sequential Organ Failure Assessment
Significant variables are indicated in bold
Results are reported as number (%), mean (%) or median [interquartile range]