Fig 1.
Gametocyte density estimates according to the cytochrome P450 reductase (CPR) status. Gametocyte density is shown as the log of pvs25 transcript levels (A) at baseline and (B) 72 hours after the initiation of the treatment. According to the conversion of pvs25 transcript levels into numbers of gametocytes published by Koepfli and colleagues (27) (1 gametocyte = 4.17 pvs25 transcripts), the median number of gametocytes is 134.8 [(IQR, 7.35–825.6) for CPRNon-Mut and 191.5 (IQR, 2.82–1,217)] for CPRMut at baseline and 0.06 (IQR, 0.0–3.09) for CPRNon-Mut and 0.85 (IQR, 0.02–23.1) for CPRMut on D3. CPRNon-Mut, CPR non-mutated; CPRMut, CPR mutated (homo and heterozygous).