TABLE 1.
Characteristics of burn patients with wound infections due to VIM-producing carbapenem-resistant organisms (n = 9)
| Characteristic | Value |
|---|---|
| Median age in years (range) | 38 (19–81) |
| Sex, n (%) | |
| Male | 7 (78) |
| Female | 2 (22) |
| Median TBSA of burn (range) | 40% (13%–65%) |
| Median LOS in days (range) | 75 (32–157) |
| Median LOS prior to isolation of CRO in days (range) | 25 (8–45) |
| Median number of surgeriesa during hospitalization (range) | 12 (1-16) |
| Associated bacteremia due to a CRO, n (%) | 4 (44) |
| VIM-CRO Isolated, n (%)b | |
| Klebsiella pneumoniae | 6 (67) |
| Serratia marcescens | 4 (44) |
| Acinetobacter baumannii | 1 (11) |
| Enterobacter cloacae | 1 (11) |
| Pseudomonas aeruginosa | 1 (11) |
| >1 species of VIM-producing CROc | 3 (33) |
| Mean Pitt bacteremia score at the time of initial CRO isolation (range)d | 2.3 (0–6) |
| Among surviving patients (n = 8) | 1.9 (0–4) |
| Treatment, n (%) | |
| Surgery alonee | 2 (22) |
| Surgery + antibiotics | 6 (67) |
| Antibiotics alonef | 1 (11) |
| Mortality, n (%) | |
| Within 30 days of initial CRO isolation | 1 (11) |
| Within 30 days of hospital discharge | 1 (11) |
| Among patients with bacteremia due to a CRO (n = 4) | 1 (25) |
Includes only amputation or debridement surgeries occurring in an operating room.
Percentages do not equal 100 due to multiple different VIM-CRO being isolated from some patients.
This includes one patient with co-culture of VIM-producing K. pneumoniae and S. marcescens, one patient with separate infections due to VIM-producing P. aeruginosa and K. pneumoniae during their hospitalization, and one patient with three separate episodes of infection due to VIM-producing K. pneumoniae, S. marcescens, and A. baumannii.
Highest Pitt bacteremia score calculated for the 24-hour period during which the initial VIM-CRO was isolated from a patient.
Refers to patients who did not receive any antibiotics expected to be active against the VIM-CRO isolate.
Refers to patients who did not have any further surgery on or after the date of their final culture containing a VIM-CRO. LOS: length of stay, TBSA: total body surface area.