TABLE 3.
Cefiderocol susceptibility testing of siderophore receptor mutants
| Strain | Cefiderocol resistance testing | ||
|---|---|---|---|
| BMD MIC (µg/mL) | Fold Increase in BMD MIC over WT | Disk susceptibility ZOI | |
| KPPR1S | 0.0625 | - | 29 mm |
| KPPR1S cirAK504fs-1 | 0.25 | 4 | 23 mm |
| KPPR1S cirAY396* | 0.125 | 2 | 24 mm |
| KPPR1S fiuE218fs-1 | 0.5 | 8 | 28 mm |
| KPPR1S fiuS653fs-1 | 0.25 | 4 | 28 mm |
| KPPR1S cirAK504fs-1, fiuE218fs-1 | 1 | 16 | 19 mm |
| KPPR1S cirAY396*, fiuS653fs-1 | 1 | 16 | 21 mm |
| Clinical Isolate A12 | 1 | - | 22 mm |
| Clinical Isolate A14 | >32 | N/A | 6 mm |
| Clinical Isolate B2 | 0.5 | - | 21 mm |
| Clinical Isolate B3 | >32 | N/A | 6 mm |