Table 4.
Analysis of the Day of Diagnosis Between Control Groups of Healthy Patients and Those With Unprovoked and Provoked Venous Thrombosis Using the Kruskal-Wallis Test. Analysis of Unprovoked Group Versus Control and Provoked Group Versus Control Using the Mann-Whitney Test.
| Biomarker | Control | Unprovoked | Provoked | Kruskal-Wallis (P value) | Mann-Whitney (P value) | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| N | Median (Q1; Q3) | 95% CI | N | Median (Q1; Q3) | 95% CI | N | Median (Q1; Q3) | 95% CI | Control × unprovoked |
Control × provoked |
||
| Anti-Xa (%) | 19 | 32.5 (14.3; 34.6) | 38.0 (14.0; 61.0) | 5 | 45.0 (36.9; 62.3) | 49.0 (31.0; 66.0) | 10 | 40.2 (32.3; 51.9) | 43.0 (33.0; 53.0) | .016 | .015 | .043 |
| PCR (ng/mL) | 9 | 1138.3 (329.2; 5667.0) | 2776.0 (355.0; 5198.0) | 5 | 11 356.3 (3567.2; 13 580.2) | 9139.0 (2538.0; 15 723.0) | 10 | 14 629.7 (7500.8; 15 978.6) | 11 815.0 (7930.0; 15 700.0) | .003 | .002 | .028 |
| D-dimer (ng/mL) | 20 | 0.0 (0.0; 155.7) | 98.0 (7.0; 189.0) | 5 | 4210.1 (2025.2; 10 581.9) | 5885.0 (416.0; 1353.0) | 10 | 7922.3 (2095.6; 14 416.0) | 8397.0 (4179.0; 12 616.0) | <.001 | <.001 | <.001 |
| PAI-1 (ng/mL) | 9 | 24.1 (19.4; 27.8) | 24.0 (18.0; 31.0) | 5 | 48.4 (9.1; 55.6) | 36.0 (5.0; 66.0) | 10 | 44.1 (21.3; 56.7) | 41.0 (26.0; 56.0) | .295 | – | – |
| TAFI (%) | 9 | 108.7 (105.4; 115.9) | 110.0 (105.0; 115.0) | 5 | 109.3 (104.9; 116.4) | 110.0 (101.0; 120.0) | 10 | 114.2 (105.9; 122.4) | 114.0 (107.0; 121.0) | .567 | – | – |
| GT (%) | 19 | 158.0 (134.9; 196.7) | 165.0 (149.0; 181.0) | 5 | 73.5 (61.3; 167.8) | 106.0 (16.0; 197.0) | 10 | 137.5 (71.0; 170.8) | 125.0 (84.0; 166.0) | .072 | – | – |
| vWF (%) | 9 | 106.4 (91.1; 112.0) | 105.0 (91.0; 117.0) | 5 | 138.8 (120.4; 155.3) | 138.0 (114.0; 162.0) | 10 | 143.5 (137.4; 157.1) | 146.0 (137.0; 156.0) | .001 | < .001 | .014 |
Abbreviations: vWF, von Willebrand factor; PAI-1, plasminogen activator inhibitor 1; NLR, neutrophil-to-lymphocyte ratio; TAFI, thrombin-activatable fibrinolysis inhibitor; PCR, polymerase chain reaction; GT: group testing.