Table 3.

List of registered clinical trials using PD-1 gene disturbed CAR-T cells/T cells to treat cancer.

NCT number	CAR-T product	Target antigen	Disease	Clinical trial phase	Status	location
NCT03525782	PD-1KO CAR-T	MUC1	NCLC	1/2	Recruiting	Guangzhou China
NCT05812326	PD-1KO CAR-T	MUC1	Breast Cancer	1/2	Recruiting	Guangzhou China
NCT03706326	PD-1KO CAR-T	MUC1	Esophageal Cancer	1/2	Recruiting	Guangzhou China
NCT03545815	PD-1/TCR KO	MSLN	Solid Tumor	1	Recruiting	Beijing China
NCT05732948	PD-1 Silence CAR-T	PSMA/PSCA	Prostate Cancer	1	Recruiting	Suzhou China
NCT03747965	PD-1 KO CAR-T	MSLN	Solid Tumor	1	Recruiting	Beijing China