Table 3.
Overview of data collection
| Variable | Baseline | 6 weeks | 12 weeks | 6 months |
| Participant characteristics | ||||
| Age | X | |||
| Sex and gender | X | |||
| Ethnicity | X | |||
| Education level | X | |||
| Health literacy (REALM) | X | |||
| Employment status | X | |||
| Smoking status | X | |||
| Civil status, living situation | X | |||
| Medical history, comorbidities | X | |||
| Knee pain/injury/surgery history | X | |||
| Objective clinical outcomes | ||||
| Height, weight, waist girth | X | X | X | |
| 30 s chair stand test | X | X | X | |
| 40 m walk test | X | X | X | |
| Body composition (DXA) | X | X | X | |
| Blood inflammatory and metabolic biomarkers | X | X | X | |
| Blood pressure | X | X | X | |
| Patient-reported Outcomes | ||||
| KOOS subscales | X | X | X | X |
| Global rating of change | X | X | X | |
| Desire for knee surgery | X | X | X | X |
| Medication use | X | X | X | X |
| Knee pain (current and worst in past week) | X | X | X | X |
| EQ-5D-5L* | X | X | X | X |
| Patient acceptable symptom state | X | X | X | X |
| Brief Pain Inventory | X | X | X | |
| International Physical Activity Questionnaire | X | X | X | |
| Kessler Psychological Distress Scale (K10) | X | X | X | |
| 3-day food diaries† | X | X | X | X |
| Adverse events | X | X | X |
*Assesses health-related quality of life across five dimensions of health (mobility, self-care, usual activities, pain/discomfort, anxiety/depression) and a Visual Analogue Scale (0–100) of current overall health status.
†3-day food diaries are also assessed prior to anti-inflammatory dietary programme consultations at 2, 4 and 9 weeks.
DXA, dual-energy X-ray absorptiometry; KOOS, Knee injury and Osteoarthritis Outcome Score; REALM, rapid estimate of adult literacy in medicine.