Table 5.

Results from Cox regression analysis of factors important for cancer-specific survival in 149 patients with clear cell renal cell carcinoma, adjusted for age, gender, tumor size (mm), tumor grade, tumor stage, and HIF-1α, HIF-2α, and HIF-3α nuclear and cytoplasmic expression levels, respectively.

Predictor	Unadjusted			Adjusteda
	RR	95% CI	P	RR	95% CI	P
Age continous	0.998	0.985–1.012	0.821	0.984	0.958–1.011	0.242
Female vs. Male	0.832	0.611–1.134	0.244	1.721	0.954–3.106	0.071
Tumor Size (mm)	1.013	1.010–1.017	< 0.001	1.006	0.998–1.014	0.114
Grade (1, 2 vs. 3,4)	2.352	1.928–2.868	< 0.001	1.511	1.108–2.059	0.009
Stage (I, II vs. III,IV)	8.365	5.659–12.366	< 0.001	8.543	4.183–17.447	< 0.001
HIF-1α-Nuclear	2.106	1.306–3.397	0.002	1.919	0.864–4.261	0.109
HIF-1α-Cytoplasm	1.428	0.897–2.275	0.133	1.010	0.805–1.267	0.930
HIF-2α-Nuclear	0.988	0.619–1.576	0.959	0.956	0.485–1.887	0.898
HIF-2α-Cytoplasm	1.039	0.633–1.705	0.881	0.891	0.423–1.875	0.760
HIF-3α-Nuclear	1.872	1.165–3.009	0.010	1.242	0.628–2.458	0.533
HIF-3α-Cytoplasm	1.635	1.028–2.600	0.038	1.504	0.740–3.058	0.260

Note: CI, confidence interval; RR, risk ratio; Tumor Size, tumor size in mm; Grade, tumor grade; Stage, TNM tumor stage; Significant P-values are given in bold.