Table 2.
Correlations between patatin like phospholipase domain containing 8 expression and clinicopathological parameters of colorectal cancer patients in this study
|
Variables
|
PNPLA8 expression
|
P value
|
|
|
Low (%)
|
High (%)
|
||
| All patients | 331 | 420 | |
| Age in yr | 0.811 | ||
| ≤ 60 | 155 (46.8) | 193 (46.0) | |
| > 60 | 176 (53.2) | 227 (54.0) | |
| Sex | 0.375 | ||
| Male | 199 (60.1) | 239 (56.9) | |
| Female | 132 (39.9) | 181 (43.1) | |
| CEA in ng/mL | 0.821 | ||
| ≤ 5 | 173 (52.3) | 223 (53.1) | |
| > 5 | 158 (47.7) | 197 (46.9) | |
| CA199 in U/mL | 0.900 | ||
| ≤ 37 | 267 (80.7) | 340 (81.0) | |
| > 37 | 64 (19.3) | 80 (19.0) | |
| Tumor location | 0.434 | ||
| Right-sided colon | 97 (29.3) | 112 (26.7) | |
| Left-sided colon | 92 (27.8) | 108 (25.7) | |
| Rectum | 142 (42.9) | 200 (47.6) | |
| Tumor size in cm | 0.589 | ||
| ≤ 4.0 | 185 (55.9) | 243 (57.9) | |
| > 4.0 | 146 (44.1) | 177 (42.1) | |
| Primary histological type | 0.848 | ||
| Non-mucinous | 283 (85.5) | 357 (85.0) | |
| Mucinous | 48 (14.5) | 63 (15.0) | |
| Primary differentiation | 0.160 | ||
| Well/moderate | 210 (63.4) | 287 (68.3) | |
| Poor/anaplastic | 121 (36.6) | 133 (31.7) | |
| T stage | 0.618 | ||
| T1/T2 | 66 (19.9) | 90 (21.4) | |
| T3/T4 | 265 (80.1) | 330 (78.6) | |
| N stage | 0.684 | ||
| N0 | 180 (54.4) | 230 (54.8) | |
| N1 | 106 (32.0) | 125 (29.8) | |
| N2 | 45 (13.6) | 65 (15.4) | |
| Vascular invasion | 0.710 | ||
| No | 287 (86.7) | 368 (87.6) | |
| Yes | 44 (13.3) | 52 (12.4) | |
| Nerve invasion | 0.638 | ||
| No | 308 (93.1) | 387 (92.1) | |
| Yes | 23 (6.9) | 33 (7.9) | |
| M stage | 0.048 | ||
| M0 | 256 (77.3) | 298 (71.0) | |
| M1 | 75 (22.7) | 122 (29.0) | |
CA199: Carbohydrate antigen 19-9; CEA: Carcinoembryonic antigen; PNPLA8: Patatin like phospholipase domain containing 8; M: Presence of metastasis; N: Extent of tumor spread to the lymph nodes; T: Extent of the tumor (the size of the tumor and any spread of tumor into nearby tissue).