Table 5.
Treatment effectiveness with patients stratified according to Helicobacter pylori status, n (%)
|
MPA effectiveness, n = 3563
|
PPI effectiveness, n = 3563
|
MPA + PPI effectiveness, n = 3563
|
MPA + PPI + PD effectiveness, n = 3563
|
P value | |||||
|
Hp (+)
|
Hp (-)
|
Hp (+)
|
Hp (-)
|
Hp (+)
|
Hp (-)
|
Hp (+)
|
Hp (-)
|
||
| Epigastric pain | 26 (47.3) | 148 (56.5) | 27 (51.9) | 86 (42.8) | 91 (67.9) | 527 (66.5) | 10 (47.6) | 161 (70.3) | 0 |
| Abdominal distension | 24 (43.6) | 143 (54.6) | 29 (55.8) | 99 (49.3) | 74 (55.2) | 424 (53.5) | 15 (71.4) | 141 (61.6) | 0.092 |
| Postprandial fullness | 21 (38.2) | 135 (51.5) | 22 (42.3) | 63 (31.3) | 55 (41.0) | 323 (40.7) | 8 (38.1) | 118 (51.5) | 0 |
| Early satiety | 19 (34.5) | 102 (38.9) | 15 (28.8) | 31 (15.4) | 36 (26.9) | 230 (29.0) | 6 (28.6) | 83 (36.2) | 0 |
| Acid regurgitation | 29 (52.7) | 102 (38.9) | 25 (48.1) | 61 (30.3) | 38 (28.4) | 340 (42.9) | 10 (47.6) | 127 (55.5) | 0 |
| Nausea | 24 (43.6) | 88 (33.6) | 15 (28.8) | 36 (17.9) | 28 (20.9) | 190 (24.0) | 2 (9.5) | 73 (31.9) | 0 |
| Belch | 28 (50.9) | 115 (43.9) | 21 (40.4) | 50 (24.9) | 37 (27.6) | 259 (32.7) | 4 (19.0) | 118 (51.5) | 0 |
| Vomiting | 16 (29.1) | 54 (20.6) | 11 (21.2) | 18 (9.0) | 17 (12.7) | 103 (13.0) | 1 (4.8) | 38 (16.6) | 0 |
| Others | 21 (38.2) | 135 (51.5) | 22 (42.3) | 63 (31.3) | 55 (41.0) | 323 (40.7) | 8 (38.1) | 118 (51.5) | 0 |
MPA: Mucosal protective agent; PPI: Proton pump inhibitor; PD: Prokinetic drug; Hp: Helicobacter pylori.