TABLE 2.
Effect of CXCR4 on infectivity of the FIV envelope glycoproteina
| Virus | Titration method | Infectivity (FFU/ml) on:
|
CrFK/CrFK.CXCR4 infectivity ratio | |
|---|---|---|---|---|
| CrFK | CrFK.CXCR4 | |||
| FIV 34TF10 | FIAb | 1.19 × 104 ± 0.89 × 104 | 9.75 × 104 ± 0.83 × 104 | 8.2 |
| Endpoint dilutionb | 5.12 × 104 | 1.15 × 106 | 22.6 | |
| CT5Δpol(FIV) | FIA | 5.3 × 104 ± 0.4 × 103 | 6.5 × 104 ± 0.9 × 104 | 12.5 |
| CT5Δpol(VSV-G) | FIA | 1.95 × 104 ± 0.1 × 105 | 1.87 × 104 ± 0.1 × 105 | 0.95 |
a
See Materials and Methods and Results for experimental details. CrFK versus CrFK.CXCR4 comparisons were performed simultaneously with the same viral preparation.
b
Different FIV preparations were used for the FIA and endpoint dilution experiments with infectious FIV.