List of drug hits increasing yeast extract productivity.

Drug	Mode of action	Targets
Bosutinib	ATP-competitive tyrosine kinase inhibitor (BCR-ABL/SRC)	Tyrosine kinases	BCR, ABL1, LYN, HCK, SRC
		Serine/threonine kinases	CDK2, MAP2K1, MAP2K2, MAP3K2, CAMK2G
		ATP-dependent efflux pump	ABCB1
Cerdulatinib	ATP-competitive tyrosine kinase inhibitor (SYK/JAK)	Tyrosine kinases	SYK, JAK1/2/3, TYK2
Dasatinib monohydrate	ATP-competitive tyrosine kinase inhibitor (SRC family)	Tyrosine kinases	ABL1/2, SRC, EPHA2/5, LCK, YES1, KIT, PDGFRB, FYN, BTK, BCR, CSK, EPHB4, FGR, FRK, LYN
		Serine/threonine kinases	ZAK, MAPK14,
		Transcription factors	STAT5B, NR4A3,
		Heat shock protein	HSPA8
		Phosphoribosyltransferase	PPAT
		ATP-dependent efflux pump	ABCB1
		ATP-binding cassette	ABCG2
Nafarelin acetate	Gonadotropin-releasing hormone (GnRH) agonist	G-protein-coupled receptors	GNRHR
Afatinib	ATP-competitive tyrosine kinase inhibitor (ErbB family)	Tyrosine kinases	EGFR, ERBB2/4
		ATP-dependent efflux pump	ABCB1
		ATP-binding cassette	ABCG2
Neratinib	ATP-competitive tyrosine kinase inhibitor (HER2/EGFR)	Tyrosine kinases	EGFR, HER2
		Serum proteins	ALB, AAG
		ATP-dependent efflux pump	ABCB1
Polymyxin B sulphate	Antibiotic	LPS of Gram-negative bacteria outer membrane	Displaces Ca2+ and Mg2+ from LPS increasing membrane permeability