TABLE 3.
Stability of tolinapant in human plasma
| Treatment | LQC | MQC | HQC |
|---|---|---|---|
| 3 ng/ml | 40 ng/ml | 360 ng/ml | |
| Room temperature (20 h) | |||
| Mean (ng/ml) ± SD | 2.86 ± 0.131 | 350 ± 8.89 | |
| CV (%) | 4.6 | 2.5 | |
| Accuracy (%) | 95.3 | 97.4 | |
| Freeze‐thaw stability (‐70○C) | |||
| Mean (ng/ml) ± SD | 2.85 ± 0.216 | 354 ± 6.75 | |
| CV (%) | 7.6 | 1.9 | |
| Accuracy (%) | 95.1 | 98.3 | |
| 419 days (–20○C) | |||
| Mean (ng/ml) ± SD | 3.27 ± 0.193 | 49.9 ± 1.22 | 379 ± 7.73 |
| CV (%) | 5.9 | 2.8 | 2.0 |
| Accuracy (%) | 109 | 107 | 105 |
| 419 days (–70○C) | |||
| Mean (ng/ml) ± SD | 3.38 ± 0.211 | 41.3 ± 1.69 | 369 ± 9.22 |
| CV (%) | 6.2 | 4.1 | 2.5 |
| Accuracy (%) | 113 | 103 | 103 |