Table 3.
Effects of the relationship between autoimmune thyroid disease and meaningful inflammatory cytokines in reverse MR analysis.
Exposure | Outcome | SNPs | Methods | Beta (95% CI) | P-value | PFDR |
---|---|---|---|---|---|---|
GD | MIP-1β | |||||
22 | MR-Egger | 0.079 (−0.032–0.191) | 0.177 | |||
22 | Weighted median | 0.055 (−0.001–0.111) | 0.054 | |||
22 | IVW | 0.049 (0.010–0.088) | 0.014 | 0.131 | ||
GD | MCP-1 | |||||
22 | MR-Egger | 0.055 (−0.049–0.159) | 0.316 | |||
22 | Weighted median | 0.063 (0.011–0.114) | 0.017 | |||
22 | IVW | 0.055 (0.019–0.092) | 0.003 | 0.082 | ||
GD | MIG | |||||
22 | MR-Egger | 0.250 (0.076–0.424) | 0.011 | |||
22 | Weighted median | 0.048 (−0.032–0.128) | 0.242 | |||
22 | IVW | 0.080 (0.014–0.146) | 0.018 | 0.131 | ||
GD | IP-10 | |||||
22 | MR-Egger | 0.180 (−0.011–0.371) | 0.080 | |||
22 | Weighted median | 0.049 (−0.038–0.136) | 0.269 | |||
22 | IVW | 0.076 (0.008–0.145) | 0.028 | 0.131 | ||
GD | SDF-1α | |||||
22 | MR-Egger | 0.021 (−0.089–0.130) | 0.716 | |||
22 | Weighted median | 0.060 (0.006–0.113) | 0.029 | |||
22 | IVW | 0.042 (0.004–0.080) | 0.030 | 0.131 | ||
GD | PDGFbb | |||||
22 | MR-Egger | −0.005 (−0.109–0.099) | 0.927 | |||
22 | Weighted median | 0.047 (−0.006–0.099) | 0.081 | |||
22 | IVW | 0.052 (0.015–0.089) | 0.006 | 0.082 | ||
GD | βNGF | |||||
22 | MR-Egger | 0.105 (−0.068–0.279) | 0.249 | |||
22 | Weighted median | 0.140 (0.058–0.222) | 0.001 | |||
22 | IVW | 0.066 (0.006–0.126) | 0.032 | 0.131 | ||
GD | IL-2ra | |||||
22 | MR-Egger | 0.134 (−0.021–0.289) | 0.106 | |||
22 | Weighted median | 0.045 (−0.031–0.122) | 0.247 | |||
22 | IVW | 0.062 (0.007–0.117) | 0.026 | 0.131 | ||
GD | IL-4 | |||||
22 | MR-Egger | 0.057 (−0.049–0.162) | 0.304 | |||
22 | Weighted median | 0.068 (0.017–0.119) | 0.009 | |||
22 | IVW | 0.054 (0.017–0.092) | 0.004 | 0.082 | ||
GD | IL-17 | |||||
22 | MR-Egger | 0.050 (−0.061–0.160) | 0.389 | |||
22 | Weighted median | 0.056 (0.001–0.110) | 0.045 | |||
22 | IVW | 0.044 (0.006–0.082) | 0.025 | 0.131 | ||
HD | MIG | |||||
22 | MR-Egger | 0.393 (0.052–0.735) | 0.050 | |||
22 | Weighted median | 0.152 (0.010–0.295) | 0.037 | |||
22 | IVW | 0.234 (0.109–0.359) | 2.35E-4 | 0.010 | ||
HD | IL-2ra | |||||
22 | MR-Egger | 0.214 (−0.070–0.498) | 0.175 | |||
22 | Weighted median | 0.100 (−0.033–0.234) | 0.141 | |||
22 | IVW | 0.136 (0.035–0.236) | 0.008 | 0.085 | ||
HD | IP-10 | |||||
22 | MR-Egger | 0.100 (−0.273–0.472) | 0.613 | |||
22 | Weighted median | 0.150 (0.010–0.290) | 0.036 | |||
22 | IVW | 0.183 (0.052–0.315) | 0.006 | 0.085 | ||
HD | IL-16 | |||||
22 | MR-Egger | 0.181 (−0.066–0.428) | 0.185 | |||
22 | Weighted median | 0.134 (0.009–0.259) | 0.036 | |||
22 | IVW | 0.124 (0.034–0.213) | 0.007 | 0.085 |
MR, Mendelian randomization analysis; SNPs, number of single-nucleotide polymorphism; CI, confidence interval; 95% CI, 95% confidence interval; PFDR, P-value was calculated by the Benjamini–Hochberg method; GD, Graves’ disease; HT, Hashimoto thyroiditis; IVW, inverse variance-weighted.