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. 2024 Mar 20;15:1334772. doi: 10.3389/fimmu.2024.1334772

Table 3.

Effects of the relationship between autoimmune thyroid disease and meaningful inflammatory cytokines in reverse MR analysis.

Exposure Outcome SNPs Methods Beta (95% CI) P-value PFDR
GD MIP-1β
22 MR-Egger 0.079 (−0.032–0.191) 0.177
22 Weighted median 0.055 (−0.001–0.111) 0.054
22 IVW 0.049 (0.010–0.088) 0.014 0.131
GD MCP-1
22 MR-Egger 0.055 (−0.049–0.159) 0.316
22 Weighted median 0.063 (0.011–0.114) 0.017
22 IVW 0.055 (0.019–0.092) 0.003 0.082
GD MIG
22 MR-Egger 0.250 (0.076–0.424) 0.011
22 Weighted median 0.048 (−0.032–0.128) 0.242
22 IVW 0.080 (0.014–0.146) 0.018 0.131
GD IP-10
22 MR-Egger 0.180 (−0.011–0.371) 0.080
22 Weighted median 0.049 (−0.038–0.136) 0.269
22 IVW 0.076 (0.008–0.145) 0.028 0.131
GD SDF-1α
22 MR-Egger 0.021 (−0.089–0.130) 0.716
22 Weighted median 0.060 (0.006–0.113) 0.029
22 IVW 0.042 (0.004–0.080) 0.030 0.131
GD PDGFbb
22 MR-Egger −0.005 (−0.109–0.099) 0.927
22 Weighted median 0.047 (−0.006–0.099) 0.081
22 IVW 0.052 (0.015–0.089) 0.006 0.082
GD βNGF
22 MR-Egger 0.105 (−0.068–0.279) 0.249
22 Weighted median 0.140 (0.058–0.222) 0.001
22 IVW 0.066 (0.006–0.126) 0.032 0.131
GD IL-2ra
22 MR-Egger 0.134 (−0.021–0.289) 0.106
22 Weighted median 0.045 (−0.031–0.122) 0.247
22 IVW 0.062 (0.007–0.117) 0.026 0.131
GD IL-4
22 MR-Egger 0.057 (−0.049–0.162) 0.304
22 Weighted median 0.068 (0.017–0.119) 0.009
22 IVW 0.054 (0.017–0.092) 0.004 0.082
GD IL-17
22 MR-Egger 0.050 (−0.061–0.160) 0.389
22 Weighted median 0.056 (0.001–0.110) 0.045
22 IVW 0.044 (0.006–0.082) 0.025 0.131
HD MIG
22 MR-Egger 0.393 (0.052–0.735) 0.050
22 Weighted median 0.152 (0.010–0.295) 0.037
22 IVW 0.234 (0.109–0.359) 2.35E-4 0.010
HD IL-2ra
22 MR-Egger 0.214 (−0.070–0.498) 0.175
22 Weighted median 0.100 (−0.033–0.234) 0.141
22 IVW 0.136 (0.035–0.236) 0.008 0.085
HD IP-10
22 MR-Egger 0.100 (−0.273–0.472) 0.613
22 Weighted median 0.150 (0.010–0.290) 0.036
22 IVW 0.183 (0.052–0.315) 0.006 0.085
HD IL-16
22 MR-Egger 0.181 (−0.066–0.428) 0.185
22 Weighted median 0.134 (0.009–0.259) 0.036
22 IVW 0.124 (0.034–0.213) 0.007 0.085

MR, Mendelian randomization analysis; SNPs, number of single-nucleotide polymorphism; CI, confidence interval; 95% CI, 95% confidence interval; PFDR, P-value was calculated by the Benjamini–Hochberg method; GD, Graves’ disease; HT, Hashimoto thyroiditis; IVW, inverse variance-weighted.