Table 4.
Heterogeneity and sensitivity analysis of meaningful inflammatory cytokines and risk of autoimmune thyroid disease.
| Exposure | Outcome | Methods | Q | P | Intercept | P | MR-PRESSO |
|---|---|---|---|---|---|---|---|
| TNF-β | GD | ||||||
| IVW | 5.795 | 0.564 | −0.015 | 0.511 | 0.650 | ||
| MR-Egger | 5.307 | 0.505 | |||||
| SCGF-β | GD | ||||||
| IVW | 25.219 | 0.339 | −0.002 | 0.915 | 0.308 | ||
| MR-Egger | 25.206 | 0.287 | |||||
| IL-12p70 | HT | ||||||
| IVW | 6.863 | 0.976 | −0.024 | 0.656 | 0.554 | ||
| MR-Egger | 6.657 | 0.966 | |||||
| IL-13 | HT | ||||||
| IVW | 19.306 | 0.253 | 0.023 | 0.759 | 0.903 | ||
| MR-Egger | 19.182 | 0.206 | |||||
| IFN-γ | HT | ||||||
| IVW | 16.508 | 0.086 | 0.084 | 0.533 | 0.759 | ||
| MR-Egger | 15.771 | 0.072 | |||||
| MCP-1 | HT | ||||||
| IVW | 24.352 | 0.499 | 0.067 | 0.330 | 0.856 | ||
| MR-Egger | 23.363 | 0.498 | |||||
| TNF-α | HT | ||||||
| IVW | 8.307 | 0.504 | −0.067 | 0.444 | 0.389 | ||
| MR-Egger | 7.658 | 0.468 |
MR-PRESSO, Mendelian randomization pleiotropy residual sum and outlier; GD, Graves’ disease; HT, Hashimoto thyroiditis; IVW, inverse variance-weighted.