Table 5.
Heterogeneity and sensitivity analysis of autoimmune thyroid disease with meaningful inflammatory cytokines.
| Exposure | Outcome | Methods | Q | P | Intercept | P | MR-PRESSO |
|---|---|---|---|---|---|---|---|
| GD | MIP-1β | ||||||
| IVW | 23.261 | 0.330 | −0.007 | 0.570 | 0.340 | ||
| MR-Egger | 22.880 | 0.295 | |||||
| GD | MCP-1 | ||||||
| IVW | 16.927 | 0.716 | 1.98E-4 | 0.986 | 0.650 | ||
| MR-Egger | 16.926 | 0.658 | |||||
| GD | MIG | ||||||
| IVW | 30.558 | 0.081 | −0.038 | 0.054 | 0.050 | ||
| MR-Egger | 25.248 | 0.192 | |||||
| GD | IP-10 | ||||||
| IVW | 32.345 | 0.054 | −0.023 | 0.270 | 0.070 | ||
| MR-Egger | 30.391 | 0.064 | |||||
| GD | SDF-1α | ||||||
| IVW | 20.976 | 0.460 | 0.005 | 0.684 | 0.510 | ||
| MR-Egger | 20.799 | 0.409 | |||||
| GD | PDGFbb | ||||||
| IVW | 14.509 | 0.847 | 0.013 | 0.266 | 0.800 | ||
| MR-Egger | 13.198 | 0.869 | |||||
| GD | βNGF | ||||||
| IVW | 24.186 | 0.284 | −0.009 | 0.642 | 0.200 | ||
| MR-Egger | 23.920 | 0.246 | |||||
| GD | IL-2ra | ||||||
| IVW | 19.698 | 0.540 | −0.016 | 0.345 | 0.560 | ||
| MR-Egger | 18.764 | 0.537 | |||||
| GD | IL-4 | ||||||
| IVW | 15.716 | 0.785 | −0.001 | 0.965 | 0.830 | ||
| MR-Egger | 15.714 | 0.734 | |||||
| GD | IL-17 | ||||||
| IVW | 21.125 | 0.451 | −0.001 | 0.911 | 0.460 | ||
| MR-Egger | 21.112 | 0.391 | |||||
| HT | MIG | ||||||
| IVW | 20.587 | 0.024 | −0.030 | 0.353 | 0.089 | ||
| MR-Egger | 18.603 | 0.029 | |||||
| HT | IL-2ra | ||||||
| IVW | 13.292 | 0.208 | −0.015 | 0.576 | 0.160 | ||
| MR-Egger | 12.814 | 0.171 | |||||
| HT | IP-10 | ||||||
| IVW | 22.664 | 0.012 | 0.016 | 0.647 | 0.510 | ||
| MR-Egger | 22.113 | 0.009 | |||||
| HT | IL-16 | ||||||
| IVW | 9.443 | 0.491 | −0.011 | 0.640 | 0.440 | ||
| MR-Egger | 9.203 | 0.419 |
MR-PRESSO, Mendelian randomization pleiotropy residual sum and outlier; GD, Graves’ disease; HT, Hashimoto thyroiditis; IVW, inverse variance-weighted.