Table 1.
Summary of pathogenic characteristics in two clusters of SARS-CoV-2.
| Characteristics | SARS-CoV-2 Clusters |
|
|---|---|---|
| PO | ABD | |
| Severity of pathologic lesion | ||
| lung | moderate | severe |
| small intestine | slight | moderate |
| large intestine | slight | severe |
| GI function-related | ||
| Apoptosis (increased*) | slight | moderate |
| AB-PAS (increased*) | moderate | severe |
| ZO-1 (decreased*) | moderatea | moderate |
| EpCAM (decreased*) | slight | moderate |
| viral load | slight | severe |
| GI inflammation | ||
| Inflammatory cytokines | slightb | severe |
| Immunoregulatory cytokines | slight | severe |
| CD4+ (increase*) | slight | Severec |
| CD8+ (increase*) | slight | Severec |
| CD68 (increase*) | slight | moderate |
| GI microbiota | ||
| Probiotics (decrease*) | slight | severe |
| conditional pathogenic bacteria (increase*) | slight | moderate3 |
| GI metabolites | ||
| SCFAs (decrease*) | slight | moderate |
| Acetate (increase*) | slight | moderate |
| Tryptophanase (increase*) | null | severe |
| Arginine (increase*) | slight | moderate |
| Fatty acid biosynthesis (increase*) | slight | moderate |
| N glycan (increase*) | slight | moderated |
| RIG-like receptor signaling pathway (increase*) | moderate | slight |
| NOD-like receptor signaling pathway (increase*) | slight | moderate |
*Compared with NC animals.
aseverely decrease in small intestine of Proto.
bmultiple inflammatory cytokines were higher in Omicron.
cseverely increase in Alpha and Delta.
dseverely decrease in Delta.