Table 6.

Histopathological Outcomes

Author, year	Group	Outcome	P Values
Guo et al. 2020	Model Treat Sham	Axons and myelinated nerves decrease, nerve density decreases and there is axonal atrophy and axonal degeneration The number of myelinated axons and nerves increases, the density of nerve fibers increases Large nerve fibers are myelinated and have densely packed endoneurium	-
Hunxiang et al. 2013	Cell transplantation group Vehicle injection group	Many nerve grafts survive and form functional connections with target muscles. More neuromuscular junction (NMJ) was obtained, ie 8.1 ± 2.4 per mm2 There is no functional relationship with the target muscle which shows no EMG response. NMJ density 1.3 ± 1.2 per mm2	<0.05
Rodriguez et al. 2021	Autograft (control) ANA ANA+BMSCs	There was no significant difference in histology between the control group, ANA, and ANA+BMSCs	-
Yang et al. 2019	Autograft (control) ANA ANA + dASCs	The percentage of NF-200 and S100 positive on autograft and ANA + dASCs was significantly higher than in the ANA group but there was no significant difference between the ANA group with autograft	< 0,05* >0.05**

* comparison between the autograft group and ANA + dASCs groups compared to the ANA group

** comparison between the autograft group with ANA group

NMJ: neuromuscular junction

BMSCs: bone marrow mesenchymal stem cells

ANA: acellular nerve allograft

dASCs: differentiated adipose stem cells

NF: neurofilament