Potential triggers responsible for the plant pathobiome prevalence. Given that plant disease epidemics arise under the scenario of global change, a series of natural and human triggers responsible for the prevalence of the plant pathobiome are highlighted. An increasing trend of plant disease outbreaks has been observed with climate change, such as global warming, and increased frequency of extreme weather events (e.g., drought stress, flooding, and storms). Global climate change has been hypothesized to trigger the plant pathobiome prevalence by promoting the assembly of the pathobiome member. As drivers of global change in the current human‐dominated epoch, anthropogenic activity (e.g., agriculture, industrialization, energy production, and transportation) and anthropogenic activity‐associated environmental pollutants further strengthen plant microbiome prevalence through a “vacuum effect,” which enable the nonnative potentially pathogenic microbes from the surrounding environment settling in below‐to‐above compartments of host plants.