Figure 5.

Potential therapeutic options for restoring gut homeostasis and treating obesity in schizophrenia. Administration of probiotics, prebiotics and fecal microbiota transplants leads to a beneficial gut microbiota composition, reduced bacterial translocation and reduced systemic inflammation. The ensuing reduction in proinflammatory cytokines may lead to reduced microglial activation, improved cognition, and reduced appetite and eating behavior. FMT, fecal microbiota transplants; IL‐1β, interleukin 1β; IL‐2, interleukin 2; IL‐6, interleukin 6; TNF‐α, tumor necrosis factor α.