Table 1.
Summary of taxonomic marker gene‐based functional prediction tools
| Tool | Description | Taxa database | Functional gene database | Functional pathway database | Link |
|---|---|---|---|---|---|
| PICRUSt2 | Ancestral‐state reconstruction based | ASVs derived from IMG | KEGG, EC number | MetaCyc | https://github.com/picrust/picrust2 |
| Tax4Fun2 | 16S rRNA gene BLAST based | Ref100NR derived from NCBI RefSeq | KEGG | https://github.com/bwemheu/Tax4Fun2 | |
| Bugbase | PICRUSt based but with clinical phenotypes | Greengenes | KEGG | https://bugbase.cs.umn.edu/index.html | |
| Piphillin | Nearest‐neighbor matching based | Manully created | KEGG | https://piphillin.secondgenome.com |
Abbreviation: KEGG, Kyoto Encyclopedia of Genes and Genomes.