Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 Feb 16;14(4):jkae030. doi: 10.1093/g3journal/jkae030

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2024. Published by Oxford University Press on behalf of The Genetics Society of America.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Fig. 2. — Transcriptomic profiling of young and old adult fly brains. a) PCA of young (0–2 d posteclosion) and old (21–25 d) H3.3A^null and H3.3^K36R fly heads, labeled by sex. b) M/A plot comparing gene expression from mixed sex H3.3^K36R and H3.3A^null young fly heads. Differentially shaded dots represent DEGs that were significantly (adjusted P-value, P-adj < 0.05) up- (red, above midline) or downregulated (blue, below). The number of DEGs in each direction is shown in the upper and lower corners. c) M/A plot of mixed sex H3.3^K36R vs H3.3A^null transcripts from old adults. Labeling and significance as per panel (b). d) Venn diagram comparing overall number of DEGs (P-adj <0.05) between H3.3A^null and H3.3^K36R genotypes, young and old mixed sex fly heads. e) Venn diagram of DEGs (P-adj < 0.05 and log₂-fold change ≥ |1|) from female H3.3^K36R (young or old) vs aged (20 d) female Chd1 fly heads. Data for Chd1 provided by Schoberleitner et al. (2021).