FIG. 2.
Relationship between blood glucose levels and the ability of influenza virus to replicate in the lungs of mice. (A) Blood glucose levels of male (▪ and □) and female (• and ○) mice were determined 4 h before i.n. infection with 105 PFU of A/Phil/82, and virus titers in the lungs were determined at 3 days postinfection. Diabetic animals are indicated by closed symbols, and nondiabetic animals are indicated by open symbols. (B) Effect of insulin treatment on replication of influenza virus in the lungs of diabetic mice. Data are the lung virus titers for individual diabetic mice (•), diabetic mice given subcutaneous injections of insulin every 6 h (⊕), and nondiabetic controls (○) 24 h after i.n. infection with 105 PFU of A/Phil/82 virus. The dashed line represents the lower limit of detection of virus in lung homogenates.