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. 2023 Jun 4;2(3):e116. doi: 10.1002/imt2.116

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© 2023 The Authors. iMeta published by John Wiley & Sons Australia, Ltd on behalf of iMeta Science.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Effects of Maca‐EVs on the metabolomics in control and UCMS mice feces. (A) Differential metabolites between New_Control and UCMS group (VIP > 1, p < 0.05, |log FC| > 1) in pos mode. (B–E) The levels of four typical metabolites that were significantly differed between New_Control and UCMS groups among sample groups. (F) Reciprocal interactions between altered gut bacteria and serum metabolites identified by a co‐occurrence network based on Spearman correlation analysis in pos mode. EV, extracellular vesicle; UCMS, unpredictable chronic mild stress. VIP, variable importance in projection.