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Potential mechanisms of BEVs biogenesis. (A) Gram‐negative bacteria cell envelope structure and related BEVs generation models, including decreased cross‐links between PG layer and outer membrane, local pressure overload, increased outer membrane curvature, LPS remodeling, and explosive cell lysis. (B) Gram‐positive bacteria cell envelope structure and related BEVs generation machinery. BEV, bacterial extracellular vesicle; LPS, lipopolysaccharide; PG, peptidoglycan.
