Figure 4.

CD8⁺ T cells play different regulatory roles and influence metabolic dysregulation. CD8⁺ T cells migrated to the liver and promoted diet‐induced MAFLD through binding to the Pro‐inflammatory chemokine receptor axis or affecting other immune cells (macrophages, neutrophils) response, but inflammatory damage was ameliorated by treatment with several anti‐inflammatory drugs. However, in special cases, CD8 + T cells inhibited fibrosis and even improved MAFLD either by restoring the balance of gut microbiota or combination therapy with drugs