FIG. 2.

The percentage of neurons latently infected and the percentage of mice that exhibited HSV reactivation following HS in ACV- and sham-treated groups. The percentage of latently infected neurons in ganglia of sham-treated mice and mice which had been treated with ACV from the time of inoculation (ACV₀) or from 36 h postinoculation (ACV₃₆) through day 7 postinoculation was determined by CXA-D. Viral reactivation was induced in mice from each of these groups. The differences between the number of latently infected neurons and the number of mice exhibiting reactivation in the sham- and ACV-treated groups were both significant (two-tailed P < 0.0001 for both ACV treatment groups, Fisher’s exact test).