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. 2024 Apr 3;14(16):10842–10857. doi: 10.1039/d4ra00629a

Fe3O4@SiO2-NH-GA-[(CH2)4-SO3H]3 catalyzed the synthesis of acridine-1,8-dionesa.

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Entry 1: 4a, 90%b Entry 2: 4b, 88% Entry 3: 4c, 94%
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Entry 4: 4d, 96% Entry 5: 4e, 85% Entry 6: 4f, 87%
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Entry 7: 4g, 87% Entry 8: 4h, 81% Entry 9: 4i, 80%
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Entry 10: 4j, 80% Entry 11: 4k, 74%c Entry 12: 4l, 70%c
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Entry 13: 4m, 83% Entry 14: 4n, 84% Entry 15: 4o, 84%
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Entry 16: 4p, 87% Entry 17: 4q, 73% Entry 18: 4r, 77%
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Entry 19: 4s, 78% Entry 20: 4t, 94% Entry 21: 4u, 96%
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Entry 22: 4v, 92% Entry 23: 4w, 94%
a

Experimental conditions: aldehyde (1.0 mmol), dimedone (2.0 mmol), and ammonium acetate/amines (1.1 mmol), catalyst (5.0 mg), in water (2.0 mL) at 60 °C.

b

Isolated yield.

c

The reaction was performed in a sealed tube.