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In vivo effect of blockage of TGF-β/Smad signaling on ATL. (A) Schematic representation of the xenograft model of ATL. (B) ATL tumor growth in mice treated with control (n = 7), SB431542 (n = 8), or SIS3-HCl (n = 7). (C and D) ATL tumor weights (normalized mean ± SD) (C) and volumes (D) in mice treated with control (n = 7), SB431542 (n = 8), or SIS3-HCl (n = 7) are shown (one-way ANOVA with Tukey correction; **P < 0.01; ***P < 0.001; ****P < 0.0001).
