Fig. 2.

The subdivision analyses of EPCAM cells, T cells and Ma/Mo cells. (a) Cell fraction difference between tumour vs. normal, relapsed vs. non-relapsed in different patient groups. P values were determined by Fisher's exact test. (b) The differences in adaptive and innate immune infiltration between tumour tissue and normal tissue in patients with all stages and late stages separately. P values were determined by Wilcoxon rank-sum test. (c) The analysis of cellular interaction in EPCAM + cell, Ma/Mo cell and T cell with different type of cells. ∗∗P ＜ 0.01; ∗∗∗P ＜ 0.001. P values were determined by Fisher's exact test. (d) Cell fraction of T cell subset in tumour/normal tissues and early/late stage. P values were determined by Fisher's exact test. (e) Cell fraction of T cell subset in tumour/normal tissues in patients with early/late stage. (f) The T cell differentiation trajectory analysis between tumour/normal tissues. (g) The heatmap of differentially-expressed transcriptomic factors between cytotoxic T cells and exhausted T cells. (h) Cell fraction of Ma/Mo subset in tumour/normal tissues, and early and late stage. P values were determined by Fisher's exact test. (i) Cell fraction of Ma/Mo cell subset in tumour/normal tissues in patients with early/late stage. (j) The Ma/Mo cell differentiation trajectory analysis. (k) The heatmap of different functions in different Ma/Mo subsets. Abbreviations: EPCAM, epithelial cell adhesion molecule; Ma/Mo, macrophage and monocyte; DEGs, differentially expressed genes.