Fig 1.

Testing the hypothesis of slow wave sleep homeostasis after dexmedetomidine sedation. (a) The synaptic homeostasis hypothesis (SHY), where wakefulness potentiates synaptic strength, and subsequent sleep SWA reflects synaptic downscaling and remodelling of circuits. (b) The hypothesis predicts that promotion of daytime sleep SWA because of the intervention will result in reduced sleep SWA on the subsequent night, thus maintaining sleep homeostasis. CLAS, closed-loop acoustic stimulation; SWA, slow wave activity. Created in BioRender.