Dexmedetomidine sedation dosed to induce EEG slow wave reduced the duration for subsequent overnight N3 sleep. (a) Boxplots comparing sleep stages pre- and post-sedation. Duration of N3 sleep was significantly lower post-vs pre-sedation (paired t-test, P=0.015). (b) As a proportion of TST, a modest reduction for N3 sleep with a corresponding modest increase in N1 sleep was observed, although this did not meet statistical significance. REM, rapid eye movement; TST, total sleep time.