Table 1.
Frequency distribution of CYP2D6 SNPs, alleles, and phenotypes.
| Variant | ID SNP | Frequency(%) | CYP2D6 allele | Allele function | Allele frequency (%) | Diplotype | Predicted phenotype | frequency (%) |
|---|---|---|---|---|---|---|---|---|
| 100C > T | rs1065852 | 55 (72.3%) | 1* | Functional | 9 (11.8) | *1/*1 | EM | 9 (11.8) |
| 1038C > T | rs1081003 | 57 (75%) | 2* | Functional | 9(11.8) | *1/*34 | EM | 1(1.3) |
| 1662 G > C | rs1058164 | 61 (80.2%) | 10* | Reduced function | 39(51.3) | *1/*39 | EM | 2(2.6) |
| 2851C > T | rs16947 | 25 (32.9%) | 34* | Functional | 1(1.3) | *2/*2 | EM | 2(2.6) |
| G4181 G > C | rs1135840 | 61 (86.9%) | 39* | Functional | 3(3.9) | *2/*34 | EM | 5(6.5) |
| 65* | Unknown | 15(19.7) | *2/*39 | EM | 2(2.6) | |||
| *10/*10 | IM | 25(32.9) | ||||||
| *10/*39 | EM | 14(18.4) | ||||||
| *39/*39 | EM | 1(1.3) | ||||||
| *10/*65 | Unknown | 15(19.7) |
Abbreviations: SNPs, single nucleotide polymorphisms; EM, extensive metabolizer; IM, intermediate metabolizer.