Table 2.
Univariable and multivariable Cox regression analysis of factors associated with cancer-specific survival in patients with bladder cancer undergoing radical cystectomy
| Univariable analysis | Multivariable analysis | |||||
|---|---|---|---|---|---|---|
| HRa | 95% CIa | p-value | HRa | 95% CIa | p-value | |
| Age (year) | 1.02 | 1.01, 1.04 | 0.003 | 1.01 | 1.00, 1.03 | 0.086 |
| Gender (Male versus female) | 1.25 | 0.83, 1.88 | 0.281 | – | – | |
| BMI (kg/m2) | 0.92 | 0.87, 0.96 | <0.001 | 0.94 | 0.90, 0.99 | 0.011 |
| Hypertension | 1.04 | 0.77, 1.42 | 0.779 | – | – | |
| Diabetes mellitus | 1.21 | 0.83, 1.78 | 0.326 | – | – | |
| ECOG PS (≥2 versus <2) | 1.18 | 0.52, 2.66 | 0.691 | – | – | |
| Diversion type (Neobladder versus Ileal conduit) | 2.15 | 1.61, 2.88 | <0.001 | 1.13 | 0.82, 1.57 | 0.458 |
| Pathologic T stage | – | – | ||||
| Less than 1 | – | – | – | – | ||
| 2 | 1.68 | 1.04, 2.71 | 0.034 | 1.20 | 0.73, 1.99 | 0.473 |
| 3 | 4.35 | 2.91, 6.52 | <0.001 | 2.29 | 1.44, 3.62 | <0.001 |
| 4 | 6.77 | 4.34, 10.5 | <0.001 | 3.23 | 1.90, 5.51 | <0.001 |
| Lymph node metastasis | 4.24 | 3.18, 5.66 | <0.001 | 2.74 | 1.86, 4.04 | <0.001 |
| Presence of CIS | 1.02 | 0.74, 1.41 | 0.908 | – | – | |
| Lymphovascular invasion | 3.48 | 2.60, 4.67 | <0.001 | 1.57 | 1.11, 2.24 | 0.011 |
| Surgical margin positive | 1.52 | 0.90, 2.58 | 0.117 | – | – | |
| Adjuvant chemotherapy | 2.65 | 1.98, 3.53 | <0.001 | 0.89 | 0.60, 1.31 | 0.560 |
| L3 SMI (cm2/m2) | 0.96 | 0.95, 0.98 | <0.001 | – | – | |
| Sarcopenia | 1.61 | 1.21, 2.14 | <0.001 | 1.49 | 1.11, 2.01 | 0.008 |
aHR Hazard Ratio, CI Confidence Interval
BMI Body mass index, ECOG Eastern Cooperative Oncology Group, PS Performance status, CIS Carcinoma in situ, SMI Skeletal muscle index