Table 3.
Univariable and multivariable Cox regression analysis of factors associated with overall survival in patients with bladder cancer undergoing radical cystectomy.
| Univariable analysis | Multivariable analysis | |||||
|---|---|---|---|---|---|---|
| HRa | 95% CIa | p-value | HRa | 95% CIa | p-value | |
| Age (year) | 1.05 | 1.04, 1.06 | <0.001 | 1.04 | 1.03, 1.06 | <0.001 |
| Gender (Male versus female) | 1.05 | 0.76, 1.47 | 0.757 | – | – | – |
| BMI (kg/m2) | 0.92 | 0.89, 0.95 | <0.001 | 0.94 | 0.90, 0.97 | <0.001 |
| Hypertension | 1.09 | 0.87, 1.38 | 0.447 | – | – | – |
| Diabetes mellitus | 1.43 | 1.09, 1.90 | 0.011 | 1.67 | 1.25, 2.24 | <0.001 |
| ECOG PS (≥2 versus <2) | 2.24 | 1.37, 3.66 | 0.001 | 1.75 | 1.06, 2.91 | 0.030 |
| Diversion type (Neobladder versus Ileal conduit) | 2.09 | 1.67, 2.60 | <0.001 | 1.05 | 0.81, 1.35 | 0.722 |
| Pathologic T stage | ||||||
| Less than 1 | – | – | – | – | – | – |
| 2 | 1.46 | 1.07, 1.99 | 0.016 | 1.14 | 0.82, 1.58 | 0.434 |
| 3 | 2.80 | 2.12, 3.69 | <0.001 | 1.92 | 1.40, 2.63 | <0.001 |
| 4 | 3.56 | 2.56, 4.96 | <0.001 | 2.20 | 1.49, 3.27 | <0.001 |
| Lymph node metastasis | 3.04 | 2.42, 3.83 | <0.001 | 2.77 | 2.02, 3.79 | <0.001 |
| Presence of CIS | 0.93 | 0.72, 1.19 | 0.565 | – | – | – |
| Lymphovascular invasion | 2.25 | 1.82, 2.80 | <0.001 | 1.27 | 0.98, 1.66 | 0.074 |
| Surgical margin positive | 1.06 | 0.67, 1.68 | 0.805 | – | – | – |
| Adjuvant chemotherapy | 1.65 | 1.31, 2.08 | <0.001 | 0.73 | 0.53, 1.01 | 0.057 |
| L3 SMI | 0.97 | 0.96, 0.98 | <0.001 | – | – | – |
| Sarcopenia | 1.47 | 1.18, 1.82 | <0.001 | 1.23 | 0.98, 1.54 | 0.071 |
aHR Hazard Ratio, CI Confidence Interval
BMI Body mass index, ECOG Eastern Cooperative Oncology Group, PS Performance status, CIS Carcinoma in situ, SMI Skeletal muscle index