Fig. 2.

VEGFR2 expression on M2-TAMs. a Summarized data for VEGFR2 expression on M1- and M2-TAMs in the normal mucosa (normal) and the tumor (tumor) by flow cytometric analysis (n = 20) (M1-TAMs; CD14+CD11c+CD163−, M2-TAMs; CD14+CD11c−CD163+). Representative histogram of VEGFR2 expression on M1- and M2-TAMs (upper). b mRNA expression z-scores in 592 samples with colorectal adenocarcinoma were obtained from TCGA (PanCancer Atlas) dataset. We utilized multi-gene expression signatures for M2-TAMs signature and the signature score was calculated by averaging the expression levels of included genes. Correlation of mRNA levels of KDR (VEGFR2) with M2-TAMs signature. *p < 0.05, ***p < 0.001, ****p < 0.0001