Table 2.
Univariable and multivariable analysis of risk factors of PFS
| Characteristics | Univariable analysis | Multivariable analysis | ||
|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | |
| Gender Male vs. female | 0.94 (0.32–2.76) | 0.915 | NA | NA |
| Age ≥ 65 versus. < 65 years | 0.77 (0.35–1.71) | 0.519 | NA | NA |
| Smoking status smoker versus. nonsmoker | 0.42 (0.18–0.97) | 0.043 | 1.29 (0.41–3.98) | 0.664 |
| Histological subtype AD versus. SCC | 2.32 (1.05–5.13) | 0.037 | 1.94 (0.68–5.56) | 0.219 |
| PD-L1 expression positive versus. negative | 0.49 (0.20–1.21) | 0.120 | NA | NA |
| tTMB ≥ 7 versus. < 7 | 0.24 (0.09–0.64) | 0.004 | 0.26 (0.08–0.84) | 0.025 |
| bTMB ≥ 11 versus. < 11 | 0.39 (0.13–1.17) | 0.092 | NA | NA |
| Stage IV versus. III | 2.41 (0.89–6.56) | 0.085 | NA | NA |
PFS progression-free survival HR hazard ratio CI confidence interval TMB tumor mutation burden tTMB tumor tissue TMB bTMB blood TMB AD adenocarcinoma SCC squamous cell carcinoma NA not available