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. 2022 Aug 17;72(3):561–578. doi: 10.1007/s00262-022-03270-w

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© The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022. Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

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Fig. 7 — Prognostic role of immune cell infiltration and STING expression in early-stage SCLC. Early-stage patients with (I-II) exhibited improved OS (vs. stage III, p < 0.001, A). KM curves demonstrate OS for oasis, stroma-oasis, infiltration-limited and desert infiltration-phenotypes according to CD45 + immune cell and CD8 + T-cell infiltration in early-stage patients (B and C), where oasis and stroma oasis tumors exhibited significantly increased OS compared to desert and infiltration limited tumors in every comparison, except for the case of CD45 oasis vs CD45 infiltration limited tumors (p = 0.145, B). There was no significant difference in OS between desert and infiltration limited tumors in any comparison. Regarding CD68, stroma oasis and oasis tumors exhibited significantly increased survival compared to desert tumors (p < 0.001, p = 0.011, respectively), but not compared to infiltration limited tumors (p = 0.094, p = 0.291, respectively) (D). When patients with only infiltrated tumors were selected (CD45 stroma oasis and oasis), stroma oasis and infiltration limited tumors showed the best prognosis (172.3 and 59.8 months, respectively) and controversially, immune oasis tumors showed the worst (21 months) (E). With the same selection (only CD45 stroma oasis and oasis tumors), patients with high tumor nest STING expression (≥ 2) showed significantly increased survival (compared to STING-low (< 2) patients, p = 0.002, G), whereas there was no significant difference in OS regarding stromal expression of STING (p = 0.125, F)