Fig. 3.

STAT3 inhibition in combination with RT significantly delays tumor growth. a Schematic showing experiment timeline. b, c Analysis of tumor growth in FC1242 and PK5L1940 murine PDAC when treated with RT alone or in combination with STAT3 ASO. Non-parametric unpaired t test was used to assess significance. Asterisks denote significance between groups (*p < 0.05, **p < 0.01, ***p < 0.001). Bars represent SEM of 7–8 mice per group. d Analysis of survival in FC1242 and PK5L1940 PDAC murine tumors when treated with RT alone or in combination with STAT3 ASO. e Analysis of tumor growth in nude mice bearing FC1242 tumors treated with RT alone or in combination with STAT3 ASO. f Analysis of tumor growth in nude mice treated with RT and RT + STAT3 ASO