Table 1.
Univariable and multivariable regression analyses of pretreatment factors associated with tumor regression grade 3/4
| Tumor regression grade ¾ | ||||
|---|---|---|---|---|
| Univariate analysis | Multivariate analysis | |||
| Odds ratio | P | Odds ratio | P | |
| Age (years) | 0.934 | 0.994 | ||
| ≤ 60 | 1.00 (reference) | 1.00 (reference) | ||
| > 60 | 1.05 (0.36, 3.03) | 1.01 (0.25, 4.17) | ||
| Sex | 0.685 | 0.403 | ||
| Male | 1.00 (reference) | 1.00 (reference) | ||
| Female | 0.81 (0.30, 2.20) | 0.58 (0.15, 2.05) | ||
| Pretreatment CEA (ng/mL) | 0.883 | 0.525 | ||
| ≤ 5 | 1.00 (reference) | 1.00 (reference) | ||
| > 5 | 0.93 (0.34, 2.50) | 0.67 (0.18, 2.30) | ||
| Distance of tumor from AV (mm) | 0.718 | 0.936 | ||
| ≤ 40 | 1.00 (reference) | 1.00 (reference) | ||
| > 40 | 0.84 (0.31, 2.23) | 0.95 (0.26, 3.40) | ||
| Clinical T category | 0.696 | 0.947 | ||
| 2/3 | 1.00 (reference) | 1.00 (reference) | ||
| 4 | 0.67 (0.08, 4.30) | 0.92 (0.07, 9.41) | ||
| Clinical N category | 0.061 | 0.119 | ||
| 0 | 1.00 (reference) | 1.00 (reference) | ||
| ½ | 0.38 (0.13, 1.04) | 0.37 (0.10, 1.29) | ||
| CD8+ TIL | < 0.001 | < 0.001 | ||
| Low | 1.00 (reference) | 1.00 (reference) | ||
| High | 7.14 (2.46, 22.9) | 7.67 (2.41, 28.2) | ||
| TCR repertoire diversity index | 0.009 | 0.049 | ||
| Low | 1.00 (reference) | 1.00 (reference) | ||
| High | 3.83 (1.40, 11.1) | 3.32 (1.00, 11.8) | ||
Values in parentheses are 95% confidence intervals
CEA carcinoembryonic antigen, AV anal verge, TIL tumor-infiltrating lymphocytes, TCR T-cell receptor