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. 2024 Feb 8;130(7):1221–1231. doi: 10.1038/s41416-024-02598-7

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Comparison of GSVA scores utilizing four TLS signatures in 43 paired pre-ICI and post-ICI samples from GSE91061. b Comparison of GSVA scores utilizing four TLS signatures in pre-ICI and post-ICI samples from GSE115821. c Systematic evlauation of TLS maturity using H&E staining and multiplex IHC of CD20, CD21, CD23, CD3, Ki67 and PanCK. d Comparison of TLS positivity between pre-ICI and post-ICI samples in the RJBLC-I2N003 cohort. e Comparison of TLS maturity between pre-ICI and post-ICI samples in the RJBLC-I2N003 cohort.