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. 2024 Feb 8;130(7):1221–1231. doi: 10.1038/s41416-024-02598-7

Fig. 5. Identification and validation of TLS induction following chemotherapy.

Fig. 5

a Relative levels of IHC staining intensities in pre-NAC (n = 92) and post-NAC (n = 60) samples. Red labels indicate a significant decrease, blue labels indicate a significant decrease, and black labels indicate no significant changes. b Relative levels of IHC staining intensities in 54 paired pre-NAC and post-NAC samples. Red labels indicate a significant decrease, blue labels indicate a significant decrease, and black labels indicate no significant changes. c Representative IHC images of paired pre-NAC and post-NAC samples. d Comparison of TLS number relative to tumor area between pre-NAC and post-NAC samples. e Comparison of TLS size relative to tumor area between pre-NAC and post-NAC samples.