Table 3.

Overall response and disease control rate to Nivolumab according to severity and subtype of thyroid dysfunction

	Overall response rate n = (%)		Disease control rate n = (%)
		p value		p value
Severity fT3/fT4 levels
Subclinical	5/12 (41.7)	0.629	7/12 (58.3)	0.292
Overt	14/28 (50)		21/28 (75.0)
Severity TSH levels
Moderate	10/19 (52.6)	0.536	12/19 (63.2)	0.369
Severe	9/21 (42.9)		16/21 (76.2)
Subtype
Isolated hypothyroidism	9/19 (47.4)	0.820	12/19 (63.2)	0.365
Isolated hyperthyroidism	5/12 (41.7)		8/12 (66.7)
Hyper/hypothyroidism	5/9 (55.6)		8/9 (88.9)