Table 2.
Classification of interventions reported in included studies based on EPOC taxonomy strategies and categories and reported rate of uptake of genetic testing for the post-intervention and control group
| EPOC taxonomy strategy | Study | EPOC taxonomy category | Intervention | Rate of uptake of genetic testing post-intervention/% | Rate of uptake of genetic testing for control group/% |
|---|---|---|---|---|---|
| Delivery arrangements | Barrow61 | Coordination of care and management of care processes | Enhanced role for GP to facilitate communication within families | – | – |
| Donenberg38 | Family counseling session by genetic counselor with local management team within 14 days of initial visit, with free single-site genetic testing. | 99.0 | – | ||
| Tone39 |
Two recruitment methods. 1. Outreach approach - clinician education and media campaigns to direct potential participants to a study website 2. Direct recruitment – letter was mailed to the deceased’s family physician to notify ARR |
93.3 | – | ||
| Dilzell32 |
Utilization of educational materials - Genetic counseling note, family letter, personal note from proband, information/report from laboratory, online resource, support group information, referral to genetics clinic |
51.0 | 19.0 | ||
| Kahn67 | Follow-up telephone call after 6 months for ARR who reported interest in genetic testing but did not return saliva kit | 35.7 | – | ||
| Yoon56 | Cancer genetic counseling session | 11 | – | ||
| Delahunty71 | Retrospective genetic testing in deceased probands, with contact of ARR | – | – | ||
| Sermijn40 |
stepwise interventional approach to inform ARR. Phase I - proband informed ARR. Phase II (after 6 months) - letter sent to ARR Phase III - phone call to obtain a final decision. |
97.8 | – | ||
| Kauffman75 | Traceback approach by using pathology specimens to identify patients with ovarian cancer and offering genetic testing to them and ARR | – | – | ||
| Frey62 | Information and communication technology (ICT) | Direct telephone contact of ARR by the genetics team, with telephone genetic counseling. Mailed saliva kit for genetic testing was provided free of charge. Telephone disclosure of genetic test results, with release of results to primary care physician | 70.0 | – | |
| O’Neil63 |
Three sessions of peer-coach lead telephone counseling |
– | – | ||
| Furniss41 | Remote genetic education and testing | 92.0 | – | ||
| Katz33 | Online cancer genetic education followed by free or paid genetic testing | 83.3 | 94.4 | ||
| Goodman65 | The use of a website as a web-based file sharing facility (Family Web website) | – | – | ||
| Schmidlen24 | family sharing tool and chatbot | – | – | ||
| Aeilts66 | 2 minute animated video for proband to share with ARR | – | – | ||
| Caswell-Jin23 | An online, low-cost family testing program | 47.5 | – | ||
| Haas69 | Integrating automated family cascade genetic testing into electronic health records | – | – | ||
| Frey70 | Direct telephone contact of ARRs made by genetics team | 70 | – | ||
| Pande72 | FamilyCONNECT online tool | – | – | ||
| Financial arrangements | Courtney21 | Collection of funds | free cascade testing | 21.6 | 6.1 |
| Li18 | Subsidy schemes -blanket and varied schemes | 53.3 | 47.5 | ||
| Kassem74 | providing predictive testing for ARR at no-charge | – | – | ||
| Implementation strategies | Chen64 | Interventions targeted at healthcare workers | ConnectMyVariant intervention to provide educational information on how to spread awareness among families | – | – |
| Garcia34 | Use of educational resources as a supplement to genetic counseling. | 4.5 | 0 | ||
| Patenaude68 | Healthcare professional-family member communication | – | – | ||
| Menko73 | Dutch guideline containing recommendations for facilitating proband-mediated disclosure | 43 | – |
GP general practitioner, ARR at-risk relatives.