Fig. 1. Decreased tumour-infiltrating cluster of differentiation (CD)8⁺ cell numbers in lung metastasis of leiomyosarcoma and correlation between the abundance of infiltrating CD8⁺ T cells and prognosis in leiomyosarcoma.

a Comparison of tumour-infiltrating immune cell numbers in primary and lung metastatic leiomyosarcoma tissues (n = 13). b Representative images of CD8 immunohistochemical (IHC) staining of leiomyosarcoma. These were primary and lung metastatic tissues from the same patient. c Comparison of CD8⁺ cell numbers in primary and lung metastatic leiomyosarcoma tissues (n = 13). The lines indicate that they were obtained from the same patient. d, e The data were obtained from The Cancer Genome Atlas cohort. Of the patients with 80 leiomyosarcomas, the top (26 patients) and bottom 1/3 (26 patients) were categorised into the high and low CD8 score groups, respectively. d Comparison of the overall survival of patients with leiomyosarcoma between the high and low CD8 score groups. e Comparison of metastasis-free survival of patients with leiomyosarcoma between high and low CD8 score groups. a, c Wilcoxon signed-rank test. *p < 0.05, **p < 0.01. d, e Log-rank test.