Fig. 7.

CD8+ T cell characteristics before and after with Pembrolizumab. a, b T-SNE and violin plot of six cell markers of CD8+ T cells (cluster 11). c Differential expression analysis, Pearson correlation analysis and overall survival analysis of cell marker TRGC2 of CD8+ T cells using TCGA database. LUAD: lung adenocarcinoma, LUSC: lung squamous cell carcinoma. *p < 0.05. d KEGG pathway enrichment analysis of differentially expressed genes in cluster 11. e The expression changes in genes involved in ribosome, chemokine signaling pathway, lysosome and Wnt signaling pathways, in before and after Pembrolizumab treatment samples. f Pearson correlation analysis between RAC2 or CXCR4 and PD-1, using TCGA database. LUAD: lung adenocarcinoma, LUSC: lung squamous cell carcinoma. *p < 0.05