Fig. 4.

Anti-tumor activities of mAb MT99/3 in Z138 xenograft model (2 × 10⁷ cells/100 µl). Z138 mantle cells were subcutaneously inoculated into 4 Gy irradiated BALB/c nude mice. mAb MT99/3 (100 µg/100 µl of PBS) or only PBS was injected into the peritoneal cavity of the mice as specified (control group: n = 10; mAb MT99/3 group: n = 12). a Comparison of tumor size between mAb MT99/3 and PBS control injection in a representative of Z138 xenograft nude mice. b Comparison of tumor size in a representative of Z138 xenograft (day 14 of treatment). c Tumor diameters were measured at the indicated time points and tumor volumes were calculated using the following formula: tumor volume = 3.14 × (W² × L)/6, where W is short diameter and L is long diameter. d Tumor weight of Z138 xenograft (day 14 of treatment). c, d Values are the mean ± SD. Unpaired t test with Welch's correction was used for comparison, **P < 0.01. ***P < 0.001. ****P < 0.0001